A xanthone and a phenylanthraquinone from the roots of, Abegaz BM, Bezabih M, Msuta T, Brun R, Menche D, Muhlbacher J, Bringmann G. Gaboroquinones A and B and 4′-O-demethylknipholone-4′-O-beta-D-glucopyranoside, phenylanthraquinones from the roots of. wulfenii, the harlequin red, yellow and orange trumpets of Justicia rizzinii and the golden leaves of Sedum mexicanum, or intertwined with the brilliant blooms of nasturtiums.The genus Bulbine belongs to the family Xanthorrhoeaceae, which includes genera such as Asphodelus, Dianella, Hemerocallis, Kniphofia and Phormium. Bulbine is also an ingredient in the first-aid herbal wound cream made during the practical session. Bulbine frutescens Planting and Care. PubMed: Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa. Lee KW, Kang NJ, Rogozin EA, Kim HG, Cho YY, Bode AM, Lee HJ, Surh YJ, Bowden GT, Dong Z. Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Bulbine frutescens. Cancer is a major public health burden in both developed and developing countries. A large number of natural products have shown in vitro antiplasmodial activities. Bulbine frutescens was reported to increase glucose utilization in Chang cells similar to the response observed for Ornithogalum longibracteatum and knipholone . New innovations in scar management. It hails from Africa and is a good groundcover plant for dry parts of the garden. Bulbine plants are adaptable to many soil types. Bolton EE, Wang Y, Thiessen PA, Bryant SH. This plant's habitat is All sorts of environments and it comes in the hardiness zone 9-15. The present in silico study was designed to assess the potential B. frutescens phytochemicals as novel natural inhibitors of signaling proteins involved in cancer. Tambama P, Abegaz B, Mukanganyama S. Antiproliferative activity of the isofuranonaphthoquinone isolated from. 3) Fungal Infections A class of naturally occurring chemicals (phytosterols) found in Bulbine natalensis blocked the growth of one of the most toxic fungi (Aspergillus flavus) [ 10 ]. J Comput Chem. There are Not Available varieties of this plant, among which some popular species are: Not available. A watery extract of Bulbine natalensis from the plant tuber completely blocked the growth of the fungi Aspergillus (niger and flavus) at all tested doses. J Global Pharma Tech. Neoplasia. Furthermore, drug-likeness property, ADME/T (absorption, distribution, metabolism, excretion/toxicity) properties, interaction ability with xenobiotic enzymes and biological activities were predicted by using various computational tools. 2017;51:1089–103. Due to its influences on cognition and sexuality, it is currently being investigated for its effects on testosterone. Bulbine frutescens (Asphodelaceae), a traditional medicinal plant in South Africa possess bioactive flavonoids and terpenoids. 217.16.190.11. However, there is no scientific information on the in vivo studies of its anti-diabetic properties PLoS One. A biochemical comparison of the in vivo effects of. Bulbine natalensis and Bulbine frutescens promote cutaneous wound healing. J Enzyme Inhib Med Chem. van Staden LF, Drewes SE. CireNat Extract Bulbine Frutescens (INCI: Bulbine Frutescens Leaf Juice) relieves skin discomfort by providing anti-itch and redness reduction effects. Note that the native leek (Bulbine bulbosa) is regarded as a toxic plant, as it can poison cattle. PubChem integrated platform of small molecules and biological activities. Bulbine. Hey AM, just happened to be researching and combing through the web looking up different test boosters and supplements containing some of these compounds touted at being big time natural test boosters and well reading several reviews/studies on one in particular by the name of bulbine … Halder SK, Beauchamp RD, Datta PK. Laskowski RA, Swindells MB. 3,3′-Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells. However, problems such as toxicity and drug resistance have stimulated an intense demand and research e orts for the 2013;8:e63697. It is generally sold under the scientific name Bulbine frutescens, though some nurseries use the synonyms B. fruticosum or B. caulescens. The evaluation of novel natural products as inhibitors of human glutathione transferase P1-1. Bulbine Natalensis is an herb from Southern and South Eastern Africa that has traditionally been used as an aphrodisiac as well as some other beneficial properties. Bulbine frutescens, which occurs in South Africa (in the provinces of Free State, 9 Northern Cape, Eastern Cape, Western Cape, and KwaZulu-Natal), Swaziland, 6 and Lesotho, 7 has yellow, sometimes orange, star-shaped flowers. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Bulbine was named a 2006 Plant of the Year by the Florida Nursery Growers and Landscape Association. Bulbine is a very important plant from Tender Perennial. Bulbine frutescens is an undemanding plant. 2010;31:455–61. The original version of this chapter was revised: the author Ajay Kumar’s affiliation was corrected. La Jolla: The Scripps Research Institute; 2010. In my experience, it multiplies rapidly. Jelly juice bulbiny shrub (Bulbine frutescens) comprises anthraquinoneknifolon and mucopolysaccharides and glycoproteins (aloktin) that has medical properties of … Bulbine likes full sun, but will grow well in semi-shade. Bulbine frutescens is often used in landscaping where a drought-resistant, tough groundcover is required. The bulb of this plant is considered to be more toxic than the flowers or stalk. The worldwide Protein Data Bank (wwpdb): ensuring a single, uniform archive of PDB data. Cite as. pp 491-510 | Gold-chrysophanol nanoparticles suppress human prostate cancer progression through inactivating AKT expression and inducing apoptosis and ROS generation in vitro and in vivo. Some species of Bulbine have toxic foliage (e.g. Discovery of natural product anticancer agents from biodiverse organisms. Arch Pharm Res. Medicine (Baltimore). Open babel: an open chemical toolbox. Part of Springer Nature. Methylated flavonoids. Bulbine frutescens. PPK and SK acknowledges financial support from UGC, India and Central University of Punjab Bathinda, Punjab, India for providing financial assistance in the form of UGC-CSIR Senior Research Fellowship and UGC-BSR Research Start-Up-Grant, [No.F.30-372/2017(BSR)] respectively. This service is more advanced with JavaScript available, Phytochemistry: An in-silico and in-vitro Update It has been suggested that this is due to an activated form of HSP90 in tumor cells. Ingestion can lead to excessive salivation, vomiting, diarrhea, loss of appetite, abdominal discomfort, lethargy, and tremors. 2003. p. 418–20. 2009;12:189–96. Int J Oncol. It might be toxic to the embryo or fetus. Matsui WH. PubMed:Bulbine natalensis and Bulbine frutescens promote cutaneous wound healing. Yellow 6-petaled star-like flowers with frilly yellow stamens on long stalks rise above the foliage in the spring through the summer. The blue felicia bush goes well with bulbs like Agapanthus, Bulbine frutescens (stalked bulbine), Eucomis autumnalis (pineapple flower), Hypoxis hemerocallidea (star flower or African potato) and Watsonia. It is a most obliging plant in the garden, growing in sun or part-shade. The root, leaf, and stem are used as medicine. Afr J Tradit Complement Altern Med. This includes the extract of Bulbine Natalensis. 2011;26:460–7. Bulbine frutescens works great as a low border plant in succulent gardens and could be used among rocks in xeriscape plantings. Dallakyan S. PyRx-python prescription v. 0.8. This succulent perennial plant (ht 40 cm) grows in wide clumps with fleshy leaves and has dainty spires of yellow starry flowers mainly in spring but also at other times during the year. Cancer stem cell signaling pathways. Induction of phase I, II and III drug metabolism/transport by xenobiotics. In conclusion, Palmidin C, AC1NSTKE and Bulbine-knipholone are the novel potent anticancer phytochemicals and need to be studied further in vitro and in vivo. 2004;13:1605–12. Pinar R. To investigate knowledge of Turkish people about cancer. Duvoix A, Morceau F, Delhalle S, Schmitz M, Schnekenburger M, Galteau MM, Dicato M, Diederich M. Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1-1 inhibition. 2011;3:33. Bringmann G, Mutanyatta-Comar J, Maksimenka K, Wanjohi JM, Heydenreich M, Brun R, Müller WE, Peter MG, Midiwo JO, Yenesew A. Joziknipholones A and B: the first dimeric phenylanthraquinones, from the roots of. Cancer treatment with gene therapy and radiation therapy. Biochem Pharmacol. Over 10 million scientific documents at your fingertips. 2009;1:4–18. Kinghorn AD, Chin YW, Swanson SM. The juice of Bulbine annua, B. lagopus is said to have antibacterial and antifungal properties when applied externally. Mukanganyama S, Bezabih M, Robert M, Ngadjui BT, Kapche GF, Ngandeu F, Abegaz B. This is a preview of subscription content, Abdissa N, Heydenreich M, Midiwo JO, Ndakala A, Majer Z, Neumann B, Stammler HG, Sewald N, Yenesew A. The ingredient also promotes skin recovery processes and increases skin hydration via natural lipid synthesis. The Bulbine frutescens extract is used in the therapeutic or cosmetic fields and has an especially good effect on diseases of the skin and mucous membranes, in particular infections or inflammations such as fungal diseases, in prevention and/or curing injuries to the skin and mucous membranes, in particular burn wounds, as a disinfectant, as an agent to improve the immune defense, for body care, oral care, … J Cheminform. Bulbine bulbosa, Australia) especially to livestock, although the tubers of this and other species are roasted and eaten by bushmen. Mouli KC, Vijaya T, Rao SD. © Springer Nature Singapore Pte Ltd. 2019, Phytochemistry: An in-silico and in-vitro Update, https://doi.org/10.1007/978-981-13-6920-9_32, Department of Biochemistry and Microbial Sciences, https://doi.org/10.1007/978-981-13-6920-9_26. Knipholone from. Berman H, Henrick K, Nakamura H, Markley JL. Anticancer and mode of action of various phytochemicals present in the plant not yet has been studied. She is enjoys well-drained soil, enriched with a little compost, but will grow in almost any soil. Bulbine frutescens L. (Willd) was the only plant mentioned in this family . Cells were exposed to the isofuranonaphthoquinone (IFNQ) at different concentrations. 2003;66:1475–83. © 2020 Springer Nature Switzerland AG. Also known as Kopieva, Geelkwassie or Bulbine frutescens, it is a common garden plant widespread in South Africa, loved by honey bees for its pollen.It’s waterwise, especially as a massive ground cover, drought resistant and enjoys rockeries too. Chen X, Du Y, Nan J, Zhang X, Qin X, Wang Y, Hou J, Wang Q, Yang J. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. It needs frost protection. The effects of the compound on cell viability were found to be irreversible. Nucleic Acids Res. Not logged in The PreADME approach: web-based program for rapid prediction of physico-chemical, drug absorption and drug-like properties. Some species (Bulbine natalensis)are aphrodisiacs, at the same time, if swallowed, they have a negative effect on the kidneys and liver. van Huyssteen M, Milne PJ, Campbell EE, van de Venter M. Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa. Flavonoids are an important class of phytochemical. Aesthet Plast Surg. These phytochemicals have better potential to inhibit NFkB, TGF-β, PI3K, and JAK2 proteins than their respective standard inhibitors. Lead phytochemicals showed better ADME/T, drug-likeness, xenobiotic enzymes interactions and biological activities. 2000;24:227–34. It combines beautifully with blue dwarf agapanthus, flowering at the same time. Xu C, Li CYT, Kong ANT. Bulbine Natalensis is a South African shrub that has been used in traditional medicine to treat a variety of conditions including diabetes and convulsions. Growing Bulbine flowers is a good choice for gardens in arid areas, as Bulbine plants are drought tolerant. Bulbine frutescens is a traditional medicinal plant of South Africa, has been preliminarily reported for anti-proliferative and anti-drug resistance property in cancer cells. Lee SK, Lee IH, Kim HJ, Chang GS, Chung JE, No KT. Cell proliferation was greater than 100% at 0.1-5 and 100-300 μg/ml for Bulbine natalensis and at 0.1μg/ml for Bulbine frutescens. PubMed: Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Bulbine … This succulent perennial plant (ht 40 cm) grows in wide clumps with fleshy leaves and has dainty spires of yellow starry flowers mainly in spring but also at other times during the year. Lu L, Li K, Mao YH, Qu H, Yao B, Zhong WW, Ma B, Wang ZY. Bulbine natalensis is a succulent plant that grows in parts of South Africa. The importance of plants lies in their great contribution to human life and the environment. 2007;28:1918–27. In fact, there will be 30 mg per 1 g of serving size is actual Bulbine Natalensis extract. The contact medium comprises an expressed gel from the plant Bulbine frutescens and may contain asiaticoside and panthenol. J Comput Chem. Phytoresources as potential therapeutic agents for cancer treatment and prevention. UCSF Chimera- a visualization system for exploratory research and analysis. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE. 2005;7:509–21. It looks effective with blue flowers in spring, or lime-coloured leaves. It is an easy-to-grow waterwise floriferous groundcover which, with the minimum of care, will look good all year round. Annu Rep Comput Chem. O’Boyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR. 20.1.4.2.2. According to the concept of various signaling involvement in the development of cancer, fractional inhibition of numerous targets can be more productive than single one. 2016;95:S8–S19. The importance of Bulbine is high as its benefits are more and so are Bulbine Facts.Every gardener must look for the required information on this plant before planting it. Bulbine frutescens (Asphodelaceae), a traditional medicinal plant in South Africa possess bioactive flavonoids and terpenoids. 2012;115:221–63. In conclusion, our study shows that the isofuranonaphthoquinone isolated from Bulbine frutescens possesses antiproliferative effects on Jurkat T cells. Although normal cells also express caspase-3 genes during apoptosis, this study focused exclusively on the effect of Bulbine natalensis and B. frutescens fractions (selected relative to the cytotoxicity results of B. natalensis) on the HEp-2 cell line (read cell culture and … It is very easily propagated from division of the clump. 1998;12:66–73. Bulbine frutescens is often used in landscaping where a drought-resistant, tough groundcover is required.. The effect was comparable to the anticancer agent BCNU. Adv Cancer Res. This is a clumping succulent and it continues with our theme of trying to promote plants that use less water but are still very beautiful in our landscape. Unfortunately, the Amaryllis contains toxic substances like lycorine that is poisonous to cats if eaten. The correction to this chapter is available at  https://doi.org/10.1007/978-981-13-6920-9_32. The isofuranonaphthoquinone occurs in Bulbine plant species such as Bulbine abyssinica, Bulbine capitata, and B. frutescens. The authors declare that they have no conflict of interest. 2006;35:301–3. Carcinogenesis. Curr Opin Drug Dis Dev. Trott O, Olson AJ. Wu T, Chen C, Li F, Chen Z, Xu Y, Xiao B, Tao Z. The effect of isofuranonaphthoquinone isolated from Bulbine frutescens on Jurkat T cells was determined. The linear leaves have a jelly-like juice that can apparently be used for burns, rashes, cracked skin and other dermatological ailments. The quinone moiety has been shown to possess antitumor activity and several cancer drugs in clinical use contain this entity. It has also been shown to exhibit potent aphrodisiac qualities. 2011;51:2778–86. Early identification and prioritization of these natural products with potential for novel mechanism of action, desirable pharmacokinetics and likelihood for development into drugs is advantageous. Kaliberov SA, Buchsbaum DJ. The incisional wounds were used to test tensile strength of the healed wounds using a tensiometer.In the in vitro studies, neither extract caused cytotoxicity to either the fibroblast or keratinocyte cells. Not affiliated Medicinal use of Bulbines is not recommended here. Animal studies show that it may increase testosterone, but only at specific doses - too high doses can have a negative impact on long-term health. Pather N, Viljoen AM, Kramer B. 2005;28:249. For the first time Palmidin C, AC1NSTKE, Bulbine-knipholone and 4′-Demethylknipholone 2′-β-D-glucopyranoside compounds have been reported for their anticancer potential. Bulbine frutescens is a traditional medicinal plant of South Africa, has been preliminarily reported for anti-proliferative and anti-drug resistance property in cancer cells. 2011;8:150–08. Tanespimycin is a potent HSP90 inhibitor with an IC 50 = 5 nM in a cell-free assay when HSP90 is isolated from tumor cells compared to c.500 nM when HSP90 is derived from normal cells. In spring, my plants combine well with the chartreuse heads of Euphorbia characias subsp. Anticancer and mode of action of various phytochemicals present in the plant not yet has been studied. In fact, these flowers are often found in rock gardens with poor soil just for this reason. J Chem Inf Model. Deregulated signaling pathways/processes result in uncontrolled cell proliferation and cell survival. Also, there is a flower form of Bulbine Natalensis you can find in online advertise shipping. Importance of Bulbine. It gets about a 1′ tall and spreads to about 2 feet. In a study, leukemic cells were used to determine the anticancer effects of a natural plant product from B. frutescens. These active ingedients are contained in a pharmaceutically acceptable cream. Growing Bulbine Bulbine is very easy to grow, requiring little water and minimum care. 2008;4:217–41. Adaptation to this condition often resulted in chemotherapeutic resistance in cancer cells. System for exploratory Research and analysis James CA, Morley C, AC1NSTKE, Bulbine-knipholone and 4′-Demethylknipholone compounds! And it comes in the hardiness zone 9-15 the flowers or stalk have been reported for anti-proliferative and anti-drug property. Stalks rise above the foliage in the garden, growing in sun or part-shade human life and environment! Recovery processes and increases skin hydration via natural lipid synthesis in spring, or lime-coloured leaves was reported increase... 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The green ones of various phytochemicals present in silico study was designed to the., though some nurseries use the synonyms B. fruticosum or B. caulescens for gardens arid.